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Therefore, multiple control systems have evolved to regulate the metabolic pathway which has made it difficult to elucidate the exact mechanism of the deficit, be it genetic or acquired

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The solution is simple: use folinic acid instead

Re-dissolved the sample with 100 L 0.1% formic acid and then desalted with ZipTip (ZTC18S096, Millipore, Boston, USA)

Promising phytoconstituents in diabetes-related wounds: mechanistic insights and implications